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NEEDHAM, Mass., Dec. 12, 2024 (GLOBE NEWSWIRE) -- Candel Therapeutics, Inc. (“Candel”) (Nasdaq: CADL), a clinical stage biopharmaceutical company focused on developing multimodal biological immunotherapies to help patients fight cancer, today announced the launch of an underwritten public offering of $80 million of its common stock and, in lieu of common stock to certain investors, pre-funded warrants to purchase shares of its common stock. All shares of common stock and pre-funded warrants to be sold in the offering will be offered by Candel. Candel also intends to grant the underwriters a 30-day option to purchase up to an additional $12 million of the shares of its common stock offered in the public offering under the same terms and conditions. The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or the actual size or terms of the offering. Candel intends to use the net proceeds from the offering to continue the development of our product candidates, including preparing the submission of a Biologics License Application for CAN-2409 in prostate cancer and for general corporate purposes. Citigroup, BofA Securities and Canaccord Genuity are acting as joint bookrunning managers for the offering. H.C. Wainwright & Co. is acting as lead manager for the offering. A shelf registration statement on Form S-3 relating to the shares of common stock offered in the public offering described above was filed with the Securities and Exchange Commission (the “SEC”) on August 5, 2022 and declared effective by the SEC on August 12, 2022. The offering will be made only by means of a written prospectus and prospectus supplement that form a part of the registration statement. A preliminary prospectus supplement and accompanying prospectus relating to the offering will be filed with the SEC and will be available on the SEC’s website at www.sec.gov. Copies of the preliminary prospectus supplement and the accompanying prospectus, when available, may also be obtained by contacting Citigroup Global Markets Inc., c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, New York 11717, telephone: 1-800-831-9146; BofA Securities, NC1-022-02-25, 201 North Tryon Street, Charlotte, North Carolina 28255-0001, Attention: Prospectus Department, email: dg.prospectus_requests@bofa.com; or Canaccord Genuity LLC, Attention: Syndication Department, 1 Post Office Square, 30th Floor, Boston, MA 02109, or by email at prospectus@cgf.com. This press release shall not constitute an offer to sell or the solicitation of an offer to buy the securities being offered, nor shall there be any sale of the securities being offered in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction. About Candel Therapeutics Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2) and borderline resectable pancreatic ductal adenocarcinoma (PDAC) (phase 2), and recently completed phase 2b and phase 3 clinical trials in localized, non-metastatic prostate cancer. CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing phase 1b clinical trial in recurrent high-grade glioma (rHGG). Finally, Candel’s enLIGHTENTM Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors. Forward-Looking Statements Various statements in this release concerning the timing, size, structure and completion of the proposed public offering on the anticipated terms or at all may constitute forward-looking statements for the purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995, as amended, and other federal securities laws. All such forward-looking statements are based on management’s current expectations of future events and are subject to a number of substantial risks and uncertainties, many of which are outside Candel’s control, that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include fluctuations in Candel’s stock price, changes in market conditions, the final terms of the public offering and satisfaction of customary closing conditions related to the public offering, as well as those risks more fully discussed in the section entitled “Risk Factors” in the prospectus supplement and registration statement referenced above, Candel’s Annual Report on Form 10-K for the year ended December 31, 2023, filed on March 28, 2024 with the SEC and subsequent filings with the SEC including Candel’s Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. There can be no assurance that Candel will be able to complete the public offering on the anticipated terms. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and Candel undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, unless required by law. Investor Contact: Theodore Jenkins VP, Investor Relations and Business Development Candel Therapeutics, Inc. tjenkins@candeltx.com Media Contact: Ben Shannon Vice President ICR Healthcare CandelPR@icrhealthcare.comNEW YORK -- New York City Mayor Eric Adams met with President-elect Donald Trump's incoming “border czar” on Thursday, with the Democratic mayor expressing an enthusiasm to work with the incoming administration to pursue violent criminals in the city while Trump promises mass deportations. The mayor's meeting with Tom Homan, who will oversee the southern and northern borders and be responsible for deportation efforts in the Trump administration, came as Adams has welcomed parts of the president-elect's hardline immigration platform. Adams told reporters at a brief news conference that he and Homan agreed on pursuing people who commit violent crimes in the city but did not disclose additional details or future plans. “We’re not going to be a safe haven for those who commit repeated violent crimes against innocent migrants, immigrants and longstanding New Yorkers," he said. “That was my conversation today with the border czar, to figure out how to go after those individuals who are repeatedly committing crimes in our city.” The meeting marked Adams' latest and most definitive step toward collaborating with the Trump administration, a development that has startled critics in one of the country's most liberal cities. In the weeks since Trump’s election win, Adams has mused about potentially scaling back the city’s so-called sanctuary policies and coordinating with the incoming Trump administration on immigration. He has also said migrants accused of crimes shouldn’t have due process rights under the Constitution, though he eventually walked back those comments. The mayor further stunned Democrats when he sidestepped questions last week on whether he would consider changing parties to become a Republican, telling journalists that he was part of the “American party.” Adams later clarified that he would remain a Democrat. For Adams, a centrist Democrat known for quarreling with the city's progressive left, the recent comments on immigration follow frustration with the Biden Administration over its immigration policies and a surge of international migrants in the city. He has maintained that his positions have not changed and argues he is trying to protect New Yorkers, pointing to the law-and-order platform he has staked out throughout his political career and during his successful campaign for mayor. At his news conference Thursday, Adams reiterated his commitment to New York’s generous social safety net. “We’re going to tell those who are here, who are law-abiding, to continue to utilize the services that are open to the city, the services that they have a right to utilize, educating their children, health care, public protection,” he said. “But we will not be the safe haven for those who commit violent acts.” While the education of all children present in the U.S. is already guaranteed by a Supreme Court ruling, New York also offers social services like healthcare and emergency shelter to low-income residents, including those in the country illegally. City and state grants also provide significant access to lawyers, which is not guaranteed in the immigration court as they are in the criminal court. Still, Adams’ recent rhetoric has been seen by some critics as an attempt to cozy up to Trump, who could potentially offer a presidential pardon in his federal corruption case. Adams has been charged with accepting luxury travel perks and illegal campaign contributions from a Turkish official and other foreign nationals looking to buy his influence. He has pleaded not guilty. Homan, who was Trump’s former acting U.S. Immigration and Customs Enforcement director, also met this week with Republicans in Illinois, where he called on Gov. J.B. Pritzker and Chicago Mayor Brandon Johnson, both Democrats, to start negotiations over how Trump's mass deportation plans, according to local media. Separately, New York City officials this week announced continued efforts to shrink a huge emergency shelter system for migrants because of a steady decline in new arrivals. Among the planned shelter closures is a massive tent complex built on a federally owned former airport in Brooklyn, which advocates have warned could be a prime target for Trump's mass deportation plan. Elsewhere, Republican governors and lawmakers in some states are already rolling out proposals that could help him carry out his pledge to deport millions of people living in the U.S. illegally. ___ Izaguirre reported from Albany, N.Y.
Report: Arthur Smith Interested In Returning To College For North Carolina Job - Steelers DepotTUCSON, Ariz. — As first light broke on the day before Thanksgiving, the aroma of fresh-baked bread wafted through Tucson’s Broadmoor-Broadway neighborhood. Outside of Barrio Bread , a line stretched down the block as locals and tourists alike waited patiently, eager to take home a piece of the city’s celebrated bakery for their holiday tables. For owner Don Guerra, the sight of the crowd represented more than just the success of his business. Barrio Bread (@ barriobread ) • Instagram photos and videos “Everyone’s trying to get their loaves of bread to put on their tables,” Guerra said. “It’s a proud moment for Barrio Bread, a community-supported bakery that’s all about local grains, agriculture, and gastronomy.” Guerra’s passion for community is palpable. He started Barrio Bread in his garage in 2011, coining the term “Community Supported Baker” (CSB) to describe the bakery’s mission. “This is about a community investment project,” he explained. “It’s a circular economy model where everyone participates to keep the bakery running and flourishing.” For loyal customer Joy Vargo, Barrio Bread is a Thanksgiving essential. Barrio Bread (@ barriobread ) • Instagram photos and videos “I’ve been coming here since Don was baking out of his garage,” Vargo said. “It’s amazing to watch someone so passionate bring an entire city together.” She planned to bring one of Guerra’s signature loaves to a Friendsgiving celebration for 15 she's hosting. “It’s a wonderful way to share bread with everybody,” she said. Robert Knodle, another customer, emphasized the bakery’s welcoming atmosphere. “Maybe the nicest owner I’ve ever met and the best bread I’ve ever eaten,” Knodle said. “We always buy the apricot bread — it’s perfect for Thanksgiving.” The bakery’s popularity stems not only from its quality but from Guerra’s dedication to using local ingredients. “I contract directly with farmers,” Guerra said. “We use local grains, heritage varieties, and long fermentation to create low-glycemic, low-gluten bread.” His signature Heritage loaf, featuring a saguaro cactus design, symbolizes the bakery’s roots. “I wanted the bread to speak for itself,” Guerra said. “This is who we are as Tucsonans.” Barrio Bread also gives back to the community, partnering with local organizations like the University of Arizona’s Garden Kitchen to provide bread through SNAP benefits. “Giving back is foundational,” Guerra said. “You have to give with open hands because if you don’t, you can’t receive.” Despite the long holiday lines, Guerra’s bread is accessible year-round, with options at the Food Conspiracy Co-op and other locations. “If the line is intimidating, you can always come another day — it’s worth it,” Vargo said. As Thanksgiving approaches, Guerra remains grateful. “Seeing those smiling faces, knowing they’ll share this bread with their families, it’s a reminder of what Thanksgiving is really about.”Morgan Rogers looked to have given Emery’s side another famous win when he slammed a loose ball home in stoppage time, but referee Jesus Gil Manzano ruled Diego Carlos to have fouled Juve goalkeeper Michele Di Gregorio and the goal was chalked off. Contact seemed minimal but VAR did not intervene and Villa had to settle for a point in a 0-0 draw. “With the last action, it is the interpretation of the referee,” the Spaniard said. “In England, 80 per cent of those is given a goal and it’s not a foul. It’s very soft. “But in Europe, it could be a foul. We have to accept. “Everybody will know, in England the interpretation is different. The England referees, when actions like that the interpretation is a clear no foul but in Europe that interpretation is different. “They have to be working to get the same decision when some action like that is coming. I don’t know exactly why but we knew before in the Premier League that it is different. A very controversial finish at Villa Park 😲 Morgan Rogers' late goal is ruled out for a foul on Juventus goalkeeper Michele Di Gregorio and the match ends 0-0 ❌ 📺 @tntsports & @discoveryplusUK pic.twitter.com/MyYL5Vdy3r — Football on TNT Sports (@footballontnt) November 27, 2024 “In Europe for example we are not doing a block like in England and we are not doing in front of the goalkeeper in offensive corners the same situations like in England. “When the action happened, I was thinking here in Europe it’s a foul. In England not, but in Europe I have to accept it. “At first, I thought the referee gave us a goal. In cases like that, it’s confusing because he has to wait for VAR. I don’t know what happened but I think so (the referee changed his mind with VAR).” It was a disappointment for Villa, who remain unbeaten at home in their debut Champions League campaign and are still in contention to qualify automatically for the last 16. “We were playing a favourite to be in the top eight and usually a contender to win this competition,” Emery added. “We are a team who for a long time didn’t play in Europe and the Champions League and this year is very important. “We wanted to play competitive and we are in the right way. Today to get one point is very good, we wanted to win but wanted to avoid some mistakes we made in previous games. “We have 10 points and we’re happy.” Before the game Emery called Juventus one of the “best teams in the world, historically and now”, but this was an Italian side down to the bare bones. Only 14 outfield players made the trip from Turin, with striker Dusan Vlahovic among those who stayed behind. Juve boss Thiago Motta, whose side are 19th but still in contention to reach the top eight, said: “There’s just three games left to qualify. The next home against Man City, then Brugge, then Benfica. “One at a time, as we always did with the goal to qualify for the next round. “In the end we will try and reach our goal which is to go to the next round.”
