Federal appeals court upholds law requiring sale or ban of TikTok in the US A federal appeals court panel on Friday unanimously upheld a law that could lead to a ban on TikTok as soon as next month, handing a resounding defeat to the popular social media platform as it fights for its survival in the U.S. The U.S. Court of Appeals for the District of Columbia Circuit ruled that the law - which requires TikTok to break ties with its China-based parent company ByteDance or be banned by mid-January — is constitutional, rebuffing TikTok’s challenge that the statute ran afoul of the First Amendment and unfairly targeted the platform. TikTok and ByteDance — another plaintiff in the lawsuit — are expected to appeal to the Supreme Court. Executive of Tyler Perry Studios dies when plane he was piloting crashes in Florida ATLANTA (AP) — The president of Atlanta-based Tyler Perry Studios has died when the small plane he was piloting crashed on Florida’s Gulf Coast. The studio confirmed on Saturday that Steve Mensch, its 62-year-old president and general manager, had died Friday. The crash happened in Homosassa, about 60 miles north of Tampa. Photos from the scene show the plane having come to rest upside down on a road. Mensch helped advocate for Georgia’s film tax credit of more than $1 billion a year. Perry hired Mensch to run his namesake studio in 2016. Mensch died as Perry released his war drama, “The Six Triple Eight." The film was shot at the Atlanta studio. US added a strong 227,000 jobs in November in bounce-back from October slowdown WASHINGTON (AP) — America’s job market rebounded in November, adding 227,000 workers in a solid recovery from the previous month, when the effects of strikes and hurricanes had sharply diminished employers’ payrolls. Last month’s hiring growth was up considerably from a meager gain of 36,000 jobs in October. The government also revised up its estimate of job growth in September and October by a combined 56,000. Friday’s report also showed that the unemployment rate ticked up from 4.1% in October to a still-low 4.2%. The November data provided the latest evidence that the U.S. job market remains durable even though it has lost significant momentum from the 2021-2023 hiring boom, when the economy was rebounding from the pandemic recession. Stock market today: Wall Street hits more records following a just-right jobs report NEW YORK (AP) — U.S. stocks rose to records after data suggested the job market remains solid enough to keep the economy going, but not so strong that it raises immediate worries about inflation. The S&P 500 climbed 0.2%, just enough top the all-time high set on Wednesday, as it closed a third straight winning week in what looks to be one of its best years since the 2000 dot-com bust. The Dow Jones Industrial Average dipped 0.3%, while the Nasdaq composite climbed 0.8% to set its own record. Treasury yields eased after the jobs report showed stronger hiring than expected but also an uptick in the unemployment rate. Killing of UnitedHealthcare CEO spotlights complex challenge companies face in protecting top brass NEW YORK (AP) — In an era when online anger and social tensions are increasingly directed at the businesses consumers count on, Meta last year spent $24.4 million to surround CEO Mark Zuckerberg with security. But the fatal shooting this week of UnitedHealthcare CEO Brian Thompson while walking alone on a New York City sidewalk has put a spotlight on the widely varied approaches companies take to protect their leaders against threats. And experts say the task of evaluating threats against executives and taking action to protect them is getting more difficult. One of the primary worries are loners whose rantings online are fed by others who are like-minded. It’s up to corporate security analysts to decide what represents a real threat. Days after gunman killed UnitedHealthcare's CEO, police push to ID him and FBI offers reward NEW YORK (AP) — Nearly four days after the shooting of UnitedHealthcare CEO Brian Thompson, police still do not know the gunman’s name or whereabouts or have a motive for the killing. But they have made some progress in their investigation into Wednesday's killing of the leader of the largest U.S. health insurer, including that the gunman likely left New York City on a bus soon after fleeing the scene. The also found that the gunman left something behind: a backpack that was discovered in Central Park. Police are working with the FBI, which on Friday night announced a $50,000 reward for information leading to an arrest and conviction. USDA orders nationwide testing of milk for bird flu to halt the virus The U.S. government has ordered testing of the nation’s milk supply for bird flu to better monitor the spread of the virus in dairy cows. The Agriculture Department on Friday said raw or unpasteurized milk from dairy farms and processors nationwide must be tested on request starting Dec. 16. Testing will begin in six states — California, Colorado, Michigan, Mississippi, Oregon and Pennsylvania. The move is aimed at eliminating the virus, which has infected more than 700 dairy herds in 15 states. Words on ammo in CEO shooting echo common phrase on insurer tactics: Delay, deny, defend A message left at the scene of an insurance executive’s fatal shooting echoes a phrase commonly used to describe insurer tactics to avoid paying claims. The words “deny,” “defend” and “depose” were written on the ammunition used to kill UnitedHealthcare's CEO. That's according to two officials who spoke to The Associated Press on condition of anonymity Thursday. The words are similar to the phrase “delay, deny, defend.” That's how attorneys describe insurers denying services and payment, and the title of a 2010 book critical of the industry. Police haven’t officially commented on the words. But Thompson’s shooting and the messages on the ammunition have sparked outrage on social media and elsewhere, reflecting frustration Americans have over the cost and complexity of getting care. Michigan Democrats move to protect reproductive health data before GOP takes control of House LANSING, Mich. (AP) — Democrats in Michigan are pressing to pass reproductive health care legislation before the party loses its majority with the new legislative session next year. A bill to protect digital reproductive health data including data logged on menstrual cycle tracking apps is a Democratic priority as lawmakers meet this month. Democratic women and supporters of the legislation say they are acting with new urgency before President-elect Donald Trump takes office because they don't believe his campaign promise to leave abortion to the states. The rush is also a reaction to Republicans taking control of the state House in January. Democrats kept control of the state Senate in the November election. Japan's Nippon Steel sets sights on a growing overseas market in its bid to acquire US Steel KASHIMA, Japan (AP) — The signs at Nippon Steel read: “The world through steel,” underlining why Japan’s top steelmaker is pursuing its $15 billion bid to acquire U.S. Steel. Japan's domestic market isn't growing, so Nippon Steel has its eyes on India, Southeast Asia and the United States, where populations are still growing. Nippon Steel gave reporters a tour of one of its plants in Japan on Friday. The bid for U.S. Steet is opposed by President-elect Donald Trump, President Joe Biden and American steelworkers. If the deal goes through, U.S. Steel will keep its name and its headquarters in Pittsburgh, Pennsylvania, but become subsidiary of Nippon Steel., /PRNewswire/ -- Why: Rosen Law Firm, a global investor rights law firm, reminds purchasers of common stock and those who purchased Chipotle call options or sold put options of Chipotle Mexican Grill, Inc. (NYSE: CMG) between and , both dates inclusive (the "Class Period"), of the important lead plaintiff deadline in the securities class action first filed by the Firm. So what: If you purchased Chipotle securities during the Class Period you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement. What to do next: To join the Chipotle class action, go to or call toll-free at 866-767-3653 or email for information on the class action. A class action lawsuit has already been filed. If you wish to serve as lead plaintiff, you must move the Court no later than . A lead plaintiff is a representative party acting on behalf of other class members in directing the litigation. Why Rosen Law: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Many of these firms do not actually litigate securities class actions, but are merely middlemen that refer clients or partner with law firms that actually litigate the cases. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm achieved the largest ever securities class action settlement against a Chinese Company at the time. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over for investors. In 2020, founding partner was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers. Details of the case: According to the lawsuit, defendants throughout the Class Period made materially false and/or misleading statements and/or failed to disclose that: (1) Chipotle's portion sizes were inconsistent and left many customers dissatisfied with the Company's offerings; (2) in order to address the issue and retain customer loyalty, Chipotle would have to ensure more generous portion sizes, which would increase cost of sales; and (3) as a result, defendants' statements about its business, operations, and prospects were materially false and misleading and/or lacked a reasonable basis at all times. When the true details entered the market, the lawsuit claims that investors suffered damages. To join the Chipotle class action, go to call toll-free at 866-767-3653 or email for information on the class action. No Class Has Been Certified. Until a class is certified, you are not represented by counsel unless you retain one. You may select counsel of your choice. You may also remain an absent class member and do nothing at this point. An investor's ability to share in any potential future recovery is not dependent upon serving as lead plaintiff. Follow us for updates on LinkedIn: or on Twitter: or on Facebook: . Attorney Advertising. Prior results do not guarantee a similar outcome. Contact Information: The Rosen Law Firm, P.A. 275 Madison Avenue, 40 Floor , NY 10016 Tel: (212) 686-1060 Toll Free: (866) 767-3653 Fax: (212) 202-3827 View original content to download multimedia: SOURCE THE ROSEN LAW FIRM, P. A.646jili01 。

Rarely does a college basketball game provide such stark contrast between the sport's haves and have-nots as when Jackson State faces No. 9 Kentucky on Friday in Lexington, Ky. While Kentucky claims eight NCAA Tournament crowns and the most wins in college basketball history, Jackson State has never won an NCAA Tournament game and enters the matchup looking for its first win of the season. Impressive tradition and current record aside, Kentucky (4-0) returned no scholarship players from last season's team that was knocked off by Oakland in the NCAA Tournament. New coach Mark Pope and his essentially all-new Wildcats are off to a promising start. Through four games, Kentucky is averaging 94.3 points per game, and with 11.5 3-pointers made per game, the team is on pace to set a school record from long distance. The Wildcats boast six double-figure scorers with transfer guards Otega Oweh (from Oklahoma, 15.0 ppg) and Koby Brea (from Dayton, 14.5 ppg) leading the team. The Wildcats defeated Duke 77-72 on Nov. 12 but showed few signs of an emotional letdown in Tuesday's 97-68 win over a Lipscomb team picked to win the Atlantic Sun Conference in the preseason. Kentucky drained a dozen 3-pointers while outrebounding their visitors 43-28. Guard Jaxson Robinson, held to a single point by Duke, dropped 20 points to lead the Kentucky attack. Afterward, Pope praised his team's focus, saying, "The last game was over and it was kind of on to, ‘How do we get better?' That's the only thing we talk about." Lipscomb coach Lennie Acuff also delivered a ringing endorsement, calling Kentucky "the best offensive Power Four team we've played in my six years at Lipscomb." Jackson State (0-5) and third-year coach Mo Williams are looking for something positive to build upon. Not only are the Tigers winless, but they have lost each game by nine or more points. Sophomore guard Jayme Mitchell Jr. (13.8 ppg) is the leading scorer, but the team shoots just 35.8 percent while allowing opponents to shoot 52.3 percent. The Tigers played on Wednesday at Western Kentucky, where they lost 79-62. Reserve Tamarion Hoover had a breakout game with 18 points to lead Jackson State, but the host Hilltoppers canned 14 3-point shots and outrebounded the Tigers 42-35 to grab the win. Earlier, Williams, who played against Kentucky while a student at Alabama, admitted the difficulties of a challenging nonconference schedule for his team. "Our goal is not to win 13 nonconference games," Williams said. "We're already at a disadvantage in that regard. We use these games to get us ready for conference play and for March Madness." Jackson State has not made the NCAA Tournament since 2007. The Tigers had a perfect regular-season record (11-0) in the Southwestern Athletic Conference in 2020-21 but lost in the league tournament. Kentucky has never played Jackson State before, but the game is being billed as part of a Unity Series of matchups in which Kentucky hosts members of the SWAC to raise awareness of Historical Black Colleges and Universities and provide funds for those schools. Past Unity Series opponents have been Southern in December 2021 and Florida A&M in December 2022. --Field Level MediaIt will be the Apaches vs. Bulldogs on Saturday with a football title at stake. Tyler Junior College, ranked No. 7 in the nation, and No. 6 Navarro College meet for the Southwest Junior College Football Conference championship at Christus Trinity Mother Frances Rose Stadium. Kickoff is scheduled for 3 p.m. on Earl Campbell Field. The winner of the SWJCFC earns a berth in the C.H.A.M.P.S. Heart of Texas Bowl, which is scheduled for Dec. 7 at Ernest Hawkins Field at Memorial Stadium on the campus of East Texas A&M University in Commerce. The Apaches (7-3) have won 11 league championships, but none in almost a quarter of a century. TJC won the 2000 SWJCFC championship with a 23-21 win over Northeastern Oklahoma A&M in the Red River Bowl held at Pennington Field in Bedford. The Apaches last played for the title in 2021, falling to New Mexico Military Institute, 45-10, in Roswell, New Mexico. The Bulldogs (7-2) have captured 12 conference titles, the last in 2019, a 36-35 win over NMMI in Corsicana. Current Navarro Coach Ryan Taylor, a former TJC All-America center, led Cisco College to the 2020 crown. (The season was played in the spring of 2021 due to COVID-19). Navarro played for the title last season, falling to Kilgore College, 48-39, in Kilgore. The last time the two met in the championship was in 2011, a 33-29 win by Navarro in Corsicana. The last time the championship game was held in Tyler was in 2003 (NEO won over TJC, 37-34). TJC advanced to the championship with a 28-17 win over Kilgore College last week in the semifinals. In six games, quarterback Tre Guerra, a sophomore from Keller, has connected on 54 of 85 passing attempts for 618 yards with four touchdowns and no interceptions. Lonnie Johnson has been a favorite target of Guerra. The big tight end who graduated from Keller Timber Creek, a rival squad of Guerra’s Keller High team, has 18 receptions on the season for 213 yards and three touchdowns (2 against KC last week). Bernock Iya (6-2, sophomore, Azle) is not only a key defensive back, but the speedster is a threat on kickoff and punt returns. William Cornelson (6-2, 240, sophomore, linebacker, Austin/Cedar Park Vista Ridge High School) leads the Apaches with 114 tackles (7.5 sacks) followed by Darion White (6-2, 215, sophomore, linebacker, Waco/La Vega High School) with 113 tackles (5.5 sacks, 2 forced fumbles). Both are among the nation’s leaders. Jayden Madkins (6-2, 290, sophomore, defensive lineman, Houston/Alvin Shadow Creek) leads the big guys up front. He has four sacks. Navarro advanced to the championship with a 28-21 win over Cisco last week in Corsicana. Bulldog quarterback Mason Shorb completed 19-of-31 passes for 259 yards and three touchdowns against Wrangler and backup QB Ryan Shackleton was 3-of-4 for 41 yards and a TD. Cisco gave the Dawgs all they wanted and more, and Navarro’s defense had to put the game away in the second half, breaking free from a 21-21 tie at halftime. Shawn Brown caught three passes for 71 yards and two touchdowns, including a 56-yarder, and Braylon Finney had three receptions for 28 yards and a TD. Malachai Jackson caught four passes for 74 yards. Navarro has won three-straight over the Apaches since TJC won 69-57 on Sept. 11, 2021. On Nov. 2, Navarro scored a 49-24 win over TJC in Corsicana. The Bulldogs lead the all-times series with Tyler, 49-41. SMOKE SIGNALS: Tyelar Rohman, TJC assistant athletic director, said, “Fans are encouraged to wear black and participate in another Black Out to show their support as the team takes the field in their signature black uniforms.” ... Ticket prices are: general admission ($8), reserved seatbacks ($12), TJC students (Free with ID) and other students ($3 with valid student ID).

Cowboys star G Zack Martin doubtful to play vs. CommandersSage Therapeutics (NASDAQ:SAGE) Upgraded at Royal Bank of Canada– ENERGIZE-T Study Achieved Primary and All Key Secondary Endpoints in Adult Patients with Transfusion-Dependent Alpha- or Beta-Thalassemia – – ENERGIZE-T is First Phase 3 Study to Demonstrate Efficacy of an Oral, Disease-Modifying Treatment for Transfusion-Dependent Alpha- and Beta-Thalassemia – – Company Filed for Regulatory Approval of Mitapivat (PYRUKYND ® ) for the Treatment of Adult Patients with Non-Transfusion-Dependent and Transfusion-Dependent Alpha- or Beta-Thalassemia in U.S., European Union, Kingdom of Saudi Arabia and United Arab Emirates – – Live and Webcast Investor Event with Agios Leadership and Medical Experts will be Hosted in San Diego on Monday, December 9 at 7:00 a.m. PT – CAMBRIDGE, Mass., Dec. 08, 2024 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare diseases, today presented positive results from the Phase 3 ENERGIZE-T study investigating mitapivat, an oral, small molecule PK activator, in adults with transfusion-dependent alpha- or beta-thalassemia. These findings were shared in an oral presentation (abstract #409) at the 66 th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego, California. Thalassemia is a rare inherited blood disorder caused by genetic mutations that lead to a reduced production of healthy hemoglobin, compromising red blood cell development, health and survival, and resulting in chronic anemia. Patients with thalassemia often experience a range of debilitating complications, both from the disease itself and as secondary effects of common management strategies such as blood transfusions and iron chelation therapy, including organ damage, stroke, and other serious health issues. In the ENERGIZE-T trial, mitapivat demonstrated a statistically significant reduction in transfusion burden compared to placebo in patients with transfusion-dependent alpha- or beta-thalassemia, achieving its primary endpoint. Additionally, the ENERGIZE-T study met all the key secondary endpoints, with mitapivat demonstrating a statistically significant reduction in additional measures of transfusion reduction response compared to placebo. In June 2024, Agios also presented positive results from the Phase 3 ENERGIZE study, which evaluated mitapivat in adults with non-transfusion-dependent alpha- or beta-thalassemia. “Treatment options for patients with transfusion-dependent thalassemia are extremely limited, and transfusions carry serious risks, such as iron overload, infections and immune reactions. There is a significant need for alternative treatments to manage this debilitating disease,” said Maria Domenica Cappellini, M.D., professor, Internal Medicine, University of Milan, Italy. “The strong Phase 3 ENERGIZE-T results build on the positive findings from the Phase 3 ENERGIZE study in patients with non-transfusion-dependent alpha- or beta-thalassemia presented earlier this year, pointing to mitapivat as a potential transformative advancement in thalassemia care.” Phase 3 ENERGIZE-T Study Results ENERGIZE-T is a Phase 3, double-blind, randomized, placebo-controlled and multicenter 48-week study. A total of 258 patients were enrolled in the study worldwide, with 171 patients randomized to mitapivat 100 mg twice-daily (BID) and 87 patients randomized to matched placebo. The study’s primary endpoint of transfusion reduction response (TRR) was defined as a ≥50% reduction in transfused red blood cell (RBC) units with a reduction of ≥2 units of transfused RBCs in any consecutive 12-week period through Week 48 compared with baseline. A TRR was achieved by 30.4% (n=52/171) of patients in the mitapivat arm compared to 12.6% (n=11/87) of patients in the placebo arm (2-sided p=0.0003). Additionally, mitapivat demonstrated statistically significant reductions in transfusion burden compared with placebo as measured by the three key secondary endpoints of transfusion reduction response reflective of durability of response up to 36 weeks during the 48-week double-blind period. The key secondary endpoint TRR2, defined as a ≥50% reduction in transfused RBC units in any consecutive 24-week period through Week 48 compared with baseline, was achieved in 13.5% (n=23/171) versus 2.3% (n=2/87) of patients in the mitapivat and placebo arms, respectively (2-sided p=0.0003). The key secondary endpoints TRR3 and TRR4 were defined as a ≥33% and ≥50% reduction in transfused RBC units, respectively, from Week 13 through Week 48 compared with baseline. TRR3 was achieved in 14.6% (n=25/171) versus 1.1% (n=1/87) of patients in the mitapivat and placebo arms, respectively (2-sided p

How mysterious murder of United Healthcare CEO Brian Thompson sparked frenzied NYC manhunt